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LPMO symposium

2nd LPMO Symposium

Marseille (France)

7-9 November 2018

Scientific program

Invited speakers

Prof Leila Lo Leggio (University of Copenhagen, Denmark)
Prof Dennis Thiele (Duke University, USA)
Prof Kiyohiko Igarashi (University of Tokyo, Japan)
Prof Vincent Eijsink (Norwergian University of Life Sciences, Oslo, Norway)
Dr Federico Sabbadin (University of York, UK)

Wednesday 7 November

10.00     Registration open

12.00     Lunch (buffet)

14.00     Welcome!                                                                                                                                                       

Session 1: LPMO-substrate interaction (Chair: Gustav Vaaje-Kolstad, Norwegian University of Life Sciences)                                                

14.10     Leila LoLeggio (University of Copenhagen, Denmark): Insights on LPMO-substrate interactions from structural studies.

14.50     Luisa Ciano (University of York, United Kingdom): A spectroscopic investigation of protein-substrate interactions in lytic polysaccharide monooxygenases.                                                                        

15.20     Gaston Courtade (Norwegian University of Life Sciences, Norway): Cellulose oxidation by a modular LPMO.                                  

15.50-16.20: Coffee break                                                                                                                                        

16.20     Zarah Forsberg (Norwegian University of Life Sciences, Norway): Modularity as a tool to harness the power of LPMOs in polysaccharide conversion.

16.50     Mirjam Kabel (Wageningen University, The Netherlands): Diversity of LPMOs in Myceliophthora thermophila C1.

17.20-18.30: Poster session                                                                                                                                    

18.30-19.30: Meeting of the scientific committee                                                                                           

Free evening                                                                                                                                                  


Thursday 8 November

Session 2: Mechanism and chemistry (Chair: Paul Walton, University of York)                                                                      

8.40       Åsmund K. Røhr (Norwegian University of Life Sciences, Norway): Unravelling the molecular basis of the lytic polysaccharide (per)oxygenase reaction.

9.10       Finn Aachmann (Norwegian University of Life Sciences, Norway): NMR perspectives on Lytic Polysaccharide Monooxygenase.             

9.40       Morten J. Bjerrum (University of Copenhagen, Denmark): Insight into the mechanism of Cu (II)-Lytic polysaccharide monooxygenase catalysed oxidation of polysaccharide.                                                                    

10.10-10.50: Coffee break and group photo                                                                                                    

10.50     Erik Hedegård (Lund University, Sweden): Molecular mechanism of lytic polysaccharide monooxygenase.         

11.20     Jalila Simaan (Centre National de la Recherche Scientifique, France): Mechanism of copper-containing mono-oxygenases: insights from biomimetic and bioinspired complexes.

11.50     Filip Mollerup (Aalto University, Finland): Lytic polysaccharide monooxygenase presents a unique capacity for copper-catalysed Kirmse rearrangements in organic synthesis.                                                                  

12.20-13.30: Lunch                                                                                                                                                      

Session 3: Co-factors and electron donating systems (Chair/ Claus Felby, University of Copenhagen)                                        

13:30     Kiyo Igarashi (University of Tokyo, Japan): Redox contribution of CDH and LPMO on lignocellulose degradation by the white-rot fungus Phanerochaete chrysosporium.                                                             

14.10     Aniko Varnai (Norwegian University of Life Sciences, Norway): The pyrroloquinoline-quinone (PQQ)-dependent quinohemoprotein pyranose dehydrogenase from Coprinopsis cinerea (CcPDH), belonging to the AA12 family, drives LPMO action.

14.40     Dejan Petrovic (Norwegian University of Life Sciences, Norway): Role of the N-terminal histidine methylation in fungal LPMOs.

15.10-15.40: Coffee break

15.40     K. Benedikt Möllers (University of Copenhagen, Denmark): Exploring light-driven biomass degradation.

16.10     David A. Russo (University of Copenhagen, Denmark): Harnessing cyanobacterial photosynthesis for light-driven biomass degradation.

16.40     Anthi Karnaouri (Lulea University, Sweden): Evaluation of different lignins as electron donors of fungal Lytic Polysaccharide Monooxygenases.                                                                       

17.10-18.00: Poster session                                                                                                                                     

19.30: Gala dinner

Friday 9 November

Session 4: Biological role and novel families (Chair: Bernard Henrissat, Centre National de la Recherche Scientifique)                                                            

8.40       Federico Sabbadin (University of York, United Kingdom): Exploring the biological roles of a new LPMO family from invertebrates, algae and oomycetes.                                                                            

9.20       Camille F. Chastel (Institut National de la Recherche Agronomique / Institut Français du Pétrole - Energies Nouvelles, France): Characterization of a new LPMO family identified in the secretomes of Aspergillus spp.                                                                              

9.50     Kristian Frandsen (Institut National de la Recherche Agronomique, France / University of Copenhagen, Denmark): The three dimensional X-ray crystal structure of LsAA9B - a Lentinus similis AA9 protein with a N-terminal Arg.                                                                

10.20-10.50: Coffee break                                                                                                                                        

10.50     Aurore Labourel (Institut National de la Recherche Agronomique, France): Discovery and characterization of an atypical family  of cellulose-active LPMO found in ectomycorrhizal and saprotrophic fungi.                                                                            

11.20     Dennis Thiele (Duke University, United States): Copper transport and virulence driven by an LPMO in the fungal pathogen Cryptococcus neoformans.                                                                      

12.00-13.10: Lunch                                                                                                                                                      

Session 5: Biotech Applications (Chair: Katja Johnasen, University of Copenhagen)                                                                                           

13.10     Bernard Cathala (Institut National de la Recherche Agronomique, France): Lytic polysaccharide monooxygenases (LPMO) promote cellulose fiber defibrillation: a new tool for cellulose nanofibril production?                                                  

13.40     Morten Sørlie (Norwegian University of Life Sciences, Norway): The interplay between glycoside hydrolases and lytic polysaccharide monooxygenases to overpower the energetic barrier of recalcitrant polysaccharide degradation.

14.10     Vincent Eijsink (Norwegian University of Life Sciences, Norway): Recent insights into determinants of LPMO functionality in biomass processing.

14.50     General discussion/closing remarks                                                                                                    

15.10     End of symposium